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original ingenuity pathway analysis data  (Mendeley Ltd)

 
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    Mendeley Ltd original ingenuity pathway analysis data
    Lactiplantibacillus plantarum EP21 membrane vesicles containing miRNAs modify inflammation and ubiquitination pathways. (a) <t>Ingenuity</t> <t>pathway</t> <t>analysis</t> identified the gene networks associated with inflammation and ubiquitination pathways. (b) The levels of genes associated with ubiquitination, specifically TNF alpha induced protein 3 (TNFAIP3), TNFAIP3-interacting protein 1 (TINP1), and Tax1 binding protein 1 (TAX1BP1), were significantly elevated in RPE-1 cells following treatment with EP21 MV. NC refers to the negative control condition. (c) Total protein was extracted from the retina of eyes subjected to negative control, transforming growth factor β2 (TGF-β2), and EP21 MVs treatment, and the extent of protein ubiquitination was assessed using western blot analysis. (d) RPE-1 cells underwent treatment with tumor necrosis factor (TNF) α, transfection with miRNAs or co-treatment with TNFα and miRNAs for a duration of 24 hours. The level of protein ubiquitination was evaluated through western blotting. Poly-ub: polyubiquitinated protein; free-ub: free ubiquitin. Relative free ubiquitin expression levels were determined using image J software. Relative expression levels (below the lanes) were normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
    Original Ingenuity Pathway Analysis Data, supplied by Mendeley Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 86 stars, based on 1 article reviews
    original ingenuity pathway analysis data - by Bioz Stars, 2026-07
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    1) Product Images from "Harnessing Lactiplantibacillus plantarum EP21 and its membrane vesicles to inhibit myopia development"

    Article Title: Harnessing Lactiplantibacillus plantarum EP21 and its membrane vesicles to inhibit myopia development

    Journal: Gut Microbes

    doi: 10.1080/19490976.2025.2534677

    Lactiplantibacillus plantarum EP21 membrane vesicles containing miRNAs modify inflammation and ubiquitination pathways. (a) Ingenuity pathway analysis identified the gene networks associated with inflammation and ubiquitination pathways. (b) The levels of genes associated with ubiquitination, specifically TNF alpha induced protein 3 (TNFAIP3), TNFAIP3-interacting protein 1 (TINP1), and Tax1 binding protein 1 (TAX1BP1), were significantly elevated in RPE-1 cells following treatment with EP21 MV. NC refers to the negative control condition. (c) Total protein was extracted from the retina of eyes subjected to negative control, transforming growth factor β2 (TGF-β2), and EP21 MVs treatment, and the extent of protein ubiquitination was assessed using western blot analysis. (d) RPE-1 cells underwent treatment with tumor necrosis factor (TNF) α, transfection with miRNAs or co-treatment with TNFα and miRNAs for a duration of 24 hours. The level of protein ubiquitination was evaluated through western blotting. Poly-ub: polyubiquitinated protein; free-ub: free ubiquitin. Relative free ubiquitin expression levels were determined using image J software. Relative expression levels (below the lanes) were normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
    Figure Legend Snippet: Lactiplantibacillus plantarum EP21 membrane vesicles containing miRNAs modify inflammation and ubiquitination pathways. (a) Ingenuity pathway analysis identified the gene networks associated with inflammation and ubiquitination pathways. (b) The levels of genes associated with ubiquitination, specifically TNF alpha induced protein 3 (TNFAIP3), TNFAIP3-interacting protein 1 (TINP1), and Tax1 binding protein 1 (TAX1BP1), were significantly elevated in RPE-1 cells following treatment with EP21 MV. NC refers to the negative control condition. (c) Total protein was extracted from the retina of eyes subjected to negative control, transforming growth factor β2 (TGF-β2), and EP21 MVs treatment, and the extent of protein ubiquitination was assessed using western blot analysis. (d) RPE-1 cells underwent treatment with tumor necrosis factor (TNF) α, transfection with miRNAs or co-treatment with TNFα and miRNAs for a duration of 24 hours. The level of protein ubiquitination was evaluated through western blotting. Poly-ub: polyubiquitinated protein; free-ub: free ubiquitin. Relative free ubiquitin expression levels were determined using image J software. Relative expression levels (below the lanes) were normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH).

    Techniques Used: Membrane, Ubiquitin Proteomics, Binding Assay, Negative Control, Western Blot, Transfection, Expressing, Software



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    original ingenuity pathway analysis data  (Mendeley Ltd)
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    Mendeley Ltd original ingenuity pathway analysis data
    Lactiplantibacillus plantarum EP21 membrane vesicles containing miRNAs modify inflammation and ubiquitination pathways. (a) <t>Ingenuity</t> <t>pathway</t> <t>analysis</t> identified the gene networks associated with inflammation and ubiquitination pathways. (b) The levels of genes associated with ubiquitination, specifically TNF alpha induced protein 3 (TNFAIP3), TNFAIP3-interacting protein 1 (TINP1), and Tax1 binding protein 1 (TAX1BP1), were significantly elevated in RPE-1 cells following treatment with EP21 MV. NC refers to the negative control condition. (c) Total protein was extracted from the retina of eyes subjected to negative control, transforming growth factor β2 (TGF-β2), and EP21 MVs treatment, and the extent of protein ubiquitination was assessed using western blot analysis. (d) RPE-1 cells underwent treatment with tumor necrosis factor (TNF) α, transfection with miRNAs or co-treatment with TNFα and miRNAs for a duration of 24 hours. The level of protein ubiquitination was evaluated through western blotting. Poly-ub: polyubiquitinated protein; free-ub: free ubiquitin. Relative free ubiquitin expression levels were determined using image J software. Relative expression levels (below the lanes) were normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
    Original Ingenuity Pathway Analysis Data, supplied by Mendeley Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/original+ingenuity+pathway+analysis+data/pmc12320841-350-0-9?v=Mendeley+Ltd
    Average 86 stars, based on 1 article reviews
    original ingenuity pathway analysis data - by Bioz Stars, 2026-07
    86/100 stars
    		  Buy from Supplier

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    Lactiplantibacillus plantarum EP21 membrane vesicles containing miRNAs modify inflammation and ubiquitination pathways. (a) Ingenuity pathway analysis identified the gene networks associated with inflammation and ubiquitination pathways. (b) The levels of genes associated with ubiquitination, specifically TNF alpha induced protein 3 (TNFAIP3), TNFAIP3-interacting protein 1 (TINP1), and Tax1 binding protein 1 (TAX1BP1), were significantly elevated in RPE-1 cells following treatment with EP21 MV. NC refers to the negative control condition. (c) Total protein was extracted from the retina of eyes subjected to negative control, transforming growth factor β2 (TGF-β2), and EP21 MVs treatment, and the extent of protein ubiquitination was assessed using western blot analysis. (d) RPE-1 cells underwent treatment with tumor necrosis factor (TNF) α, transfection with miRNAs or co-treatment with TNFα and miRNAs for a duration of 24 hours. The level of protein ubiquitination was evaluated through western blotting. Poly-ub: polyubiquitinated protein; free-ub: free ubiquitin. Relative free ubiquitin expression levels were determined using image J software. Relative expression levels (below the lanes) were normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH).

    Journal: Gut Microbes

    Article Title: Harnessing Lactiplantibacillus plantarum EP21 and its membrane vesicles to inhibit myopia development

    doi: 10.1080/19490976.2025.2534677

    Figure Lengend Snippet: Lactiplantibacillus plantarum EP21 membrane vesicles containing miRNAs modify inflammation and ubiquitination pathways. (a) Ingenuity pathway analysis identified the gene networks associated with inflammation and ubiquitination pathways. (b) The levels of genes associated with ubiquitination, specifically TNF alpha induced protein 3 (TNFAIP3), TNFAIP3-interacting protein 1 (TINP1), and Tax1 binding protein 1 (TAX1BP1), were significantly elevated in RPE-1 cells following treatment with EP21 MV. NC refers to the negative control condition. (c) Total protein was extracted from the retina of eyes subjected to negative control, transforming growth factor β2 (TGF-β2), and EP21 MVs treatment, and the extent of protein ubiquitination was assessed using western blot analysis. (d) RPE-1 cells underwent treatment with tumor necrosis factor (TNF) α, transfection with miRNAs or co-treatment with TNFα and miRNAs for a duration of 24 hours. The level of protein ubiquitination was evaluated through western blotting. Poly-ub: polyubiquitinated protein; free-ub: free ubiquitin. Relative free ubiquitin expression levels were determined using image J software. Relative expression levels (below the lanes) were normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH).

    Article Snippet: Original Ingenuity Pathway Analysis data have been deposited at Mendeley at [DOI: 10.17632/38wctrkx3h.1] and are publicly available as of the date of publication.

    Techniques: Membrane, Ubiquitin Proteomics, Binding Assay, Negative Control, Western Blot, Transfection, Expressing, Software